Managing sickle cell patients in hospital involves giving the patient intravenous to help the C-cells that have clumped together to flow easily in the blood vessels. Increase of anemia, blood transfusion is done and the children are also regularly given anti-malarial drugs to prevent frequent attacks of malaria, since they are prone to infections.

A balanced diet should be given to sickle cell patients that is regular intake of folic acid tablets, leafy greens and vegetables, liver, salads, juice, multivitamins and oral rehydration salt fluid.

De-worming should be done after three months and the children under five years should get pneumococcal vaccine to prevent infections. The children should also avoid stressful factors like cold whether, carrying heavy things, and conducting too much exercise.